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Datasets and external resources Transcriptomic data for rodent meta-dataset Mouse and rat gene expression data for meta-analysis and clock development were obtained from the current study (ITP cohorts), published studies 66,67,68 and the repositories NCBI Gene Expression Omnibus (GEO) 69 , ArrayExpress 70 , and Sequence Read Archive (SRA) 71 via the following identifiers: GSE3150 72 , GSE6591 73 , GSE11291 74 , GSE34378 75 , GSE27625 76 , GSE53960 77 , GSE66715 78 , GSE132040 79 , GSE146977 80 , GSE145480 81 , GSE3129 72 , GSE55272 82 , GSE131754 15 , GSE81959 83 , GSE36838 84 , GSE46895 85 , GSE51108 86 , GSE26267 87 , GSE92486 88 , GSE124772 89 , GSE101657 90 , GSE117188 91 , GSE32609 2 , GSE1093 92 , GSE40977 93 , GSE48333 94 , GSE48331 94 , GSE49000 95 , GSE97074 96 , GSE108379 97 , GSE122116 98 , GSE121395 99 , GSE122080 100 , GSE122085 98 , GSE122243 101 , GSE122367 102 , GSE126814 103 , GSE127758 58 , GSE128724 102 , GSE129083 104 , GSE137504 105 , GSE139204 106 , GSE140286 107 , GSE143304 108 , GSE145972 109 , GSE146796 110 , GSE147666 111 , GSE148647 112 , GSE149569 113 , GSE155407 114 , GSE156762 115 , GSE158980 116 , GSE165409 117 , GSE154832 118 , GSE166615 119 , GSE166778 120 , GSE168211 121 , GSE168610 122 , GSE175571 123 , GSE178770 124 , GSE69952 125 , GSE78130 126 , GSE83931 127 , GSE93833, GSE124483 128 , GSE127475 129 , GSE190939 130 , GSE201207 131 , GSE141252 132 , GSE134781 133 , GSE134780 133 , GSE219203 134 , GSE149029 135 , GSE39699 136 , GSE75574 137 , GSE89272 138 , GSE54853 139 , GSE155064 140 , GSE86882 141 , GSE234563 142 , GSE51202 143 , GSE84390 144 , GSE123293 145 , GSE234667 146 , GSE52794 147 , GSE241904 148 , GSE75192 126 , PRJNA281127 149 , PRJNA516151 150 , E-MTAB-3374 151 , E-MEXP-2320 152 and E-MEXP-153 153